应数学与统计学院邀请中国科学院上海生命科学研究院系统生物重点实验室陈洛南研究员于12月2日来我校做以下学术报告，欢迎广大教师和学生参加。

题目: Detecting early-warning signals for complex diseases by dynamical network biomarkers.

时间: 2014年12月02日（星期二）, 10:00--11:00

地点: 理科楼407室

摘要: Considerable evidence suggests that during the progression of complex diseases, the deteriorations are not necessarily smooth but are abrupt, and may cause a critical transition from one state to another at a tipping point. Here, we develop a model-free method to detect early-warning signals of such critical transitions, even with only a small number of samples. Specifically, we theoretically derive an index based on a dynamical network biomarker (DNB) that serves as a general early-warning signal indicating an imminent bifurcation or sudden deterioration before the critical transition occurs. Based on theoretical analyses, we show that predicting a sudden transition from small samples is achievable provided that there are a large number of measurements for each sample, e.g., high-throughput data. We employ microarray data of three diseases to demonstrate the effectiveness of our method. The relevance of DNBs with the diseases was also validated by related experimental data and functional analysis.

陈洛南研究员简介:Prof. Chen received BS degree in the Electrical Engineering, from Huazhong University of Science and Technology, and the M.E. and Ph.D. degrees in the electrical engineering, from  Tohoku   University ,  Sendai ,   Japan , in 1988 and 1991, respectively. From 1997, he was an associate professor of the  Osaka   Sangyo   University ,  Osaka ,   Japan , and then a full Professor. Since 2010, he has been a professor and executive director at Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences,  Chinese   Academy  of Sciences. He was the founding director of  Institute  of Systems Biology ,  Shanghai   University , and from 2010 he has also been a research professor in  Institute  of  Industrial Science , University of Tokyo ,   Japan . He was elected as the founding president of Computational Systems Biology Society of OR China, and Chair of Technical Committee of Systems Biology at IEEE SMC Society. He serves as editor or editorial board member for major systems biology related journals, e.g. BMC Systems Biology, IEEE/ACM Trans. On Computational Biology and Bioinformatics, Journal of Molecular Cell Biology, Mathematical Biosciences, and Journal of the Royal Society Interface. His fields of interest are systems biology, computational biology, and nonlinear dynamics. In recent years, he published over 200 SCI journal papers and two monographs (books) in the area of systems biology.