报告人：Robert Joseph Smith
报告题目：Key factors and parameter ranges for immune control of equine infectious anemia virus infection
时间：2025年9月15日 10:00-11:30
地点：数学楼2-2
报告摘要：
Equine Infectious Anemia Virus (EIAV) is an important infection in equids whose similarity to HIV holds hope for a potential vaccine. We analyze a within-host model of EIAV infection with antibody and cytotoxic T lymphocyte (CTL) responses. In this model, the stability of the biologically relevant endemic equilibrium, characterized by coexistence of long-term antibody and CTL levels, relies upon a balance between CTL and antibody growth rates, needed to allow existence of persistent CTL levels. We determine model parameters where CTL and antibody proliferation rates are simultaneously most influential in leading the system towards coexistence and derive a mathematical relationship between CTL and antibody production rates in order to explore the bifurcation curve that leads to coexistence. We employ Latin hypercube sampling and least squares to find parameters that equally divide the endemic and boundary equilibria. We then examine this relationship numerically via a local sensitivity analysis of the parameters. Our analysis is consistent with previous results showing that an intervention, such as a vaccine, intended to control a persistent viral infection with both immune responses should moderate the antibody response to allow for stimulation of the CTL response. Finally, we show that the CTL production rate can entirely determine the long-term outcome, regardless of the effect of other parameters, and we provide the conditions for this result in terms of identified ranges for all model parameters.
报告人简介：
Robert Joseph Smith教授，加拿大渥太华大学数学与统计系终身教授。Smith 教授是国际生物数学学会的会士，且为学会自创立以来最年轻的会士获得者，已载入年鉴。其于1994年在澳大利亚麦考瑞大学数学系获学士学位，1996 年和 2001 年在加拿大麦克马斯特大学数学与统计系获硕士学位和博士学位，曾分别在美国加州大学洛杉矶分校、美国伊利诺伊大学香槟分校和加拿大西安大略大学从事博士后研究。主要从事数学流行病学的动力学模型建立、动力学性质分析、参数估计等，在 HIV/AIDS、结核病、乙型/丙型肝炎、性传播疾病、流感等传染病预防控制研究方面取得了卓越的成就，在权威期刊 Science, Lacent Infectious Disease 等发表论文 120 多篇，引次数大于 100 的论文 37 篇，主持科研项目11项，科研成果获加拿大政府奖 10 项，先后组织 20 多次国际传染病预防控制研讨会，在国际生物数学学术会议上做学术报告 60 多次，为8个期刊的主编或编委会成员，出版专著15本，其中独著6本。
邀请人：肖燕妮教授
